Antigenic structure of the hemagglutinin of H9N2 influenza viruses
Identifieur interne : 001341 ( Main/Exploration ); précédent : 001340; suivant : 001342Antigenic structure of the hemagglutinin of H9N2 influenza viruses
Auteurs : Masatoshi Okamatsu [Japon] ; Yoshihiro Sakoda [Japon] ; Noriko Kishida [Japon] ; Norikazu Isoda [Japon] ; Hiroshi Kida [Japon]Source :
- Archives of Virology [ 0304-8608 ] ; 2008-12-01.
Abstract
Abstract: The hemagglutinins (HAs) of H9 influenza viruses isolated from birds and mammals of different species were antigenically and genetically analyzed. Antigenic variants were selected from A/swine/Hong Kong/10/98 (H9N2) and A/duck/Hokkaido/13/00 (H9N2) in the presence of monoclonal antibodies (MAbs). Based on the reactivity patterns of these mutants with a panel of MAbs, at least five non-overlapping antigenic sites were defined using eight MAbs which recognized seven distinct epitopes on the H9 HA molecule. Based on the reactivity patterns with the panel of monoclonal antibodies, 21 H9N2 virus strains isolated from birds and mammals were divided into 7 antigenically distinct groups. The present findings indicate that it is important to monitor the antigenic variation in H9 influenza viruses. The panel of MAbs in the present study, thus, should be useful for detailed antigenic analysis of the H9 HAs for epidemiological studies, the selection of vaccine strains, and diagnosis.
Url:
DOI: 10.1007/s00705-008-0243-2
Affiliations:
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level="j" type="sub">Official Journal of the Virology Division of the International Union of Microbiological Societies</title><title level="j" type="abbrev">Arch Virol</title><idno type="ISSN">0304-8608</idno><idno type="eISSN">1432-8798</idno><imprint><publisher>Springer Vienna</publisher><pubPlace>Vienna</pubPlace><date type="published" when="2008-12-01">2008-12-01</date><biblScope unit="volume">153</biblScope><biblScope unit="issue">12</biblScope><biblScope unit="page" from="2189">2189</biblScope><biblScope unit="page" to="2195">2195</biblScope></imprint><idno type="ISSN">0304-8608</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0304-8608</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: The hemagglutinins (HAs) of H9 influenza viruses isolated from birds and mammals of different species were antigenically and genetically analyzed. Antigenic variants were selected from A/swine/Hong Kong/10/98 (H9N2) and A/duck/Hokkaido/13/00 (H9N2) in the presence of monoclonal antibodies (MAbs). Based on the reactivity patterns of these mutants with a panel of MAbs, at least five non-overlapping antigenic sites were defined using eight MAbs which recognized seven distinct epitopes on the H9 HA molecule. Based on the reactivity patterns with the panel of monoclonal antibodies, 21 H9N2 virus strains isolated from birds and mammals were divided into 7 antigenically distinct groups. The present findings indicate that it is important to monitor the antigenic variation in H9 influenza viruses. The panel of MAbs in the present study, thus, should be useful for detailed antigenic analysis of the H9 HAs for epidemiological studies, the selection of vaccine strains, and diagnosis.</div></front></TEI><affiliations><list><country><li>Japon</li></country></list><tree><country name="Japon"><noRegion><name sortKey="Okamatsu, Masatoshi" sort="Okamatsu, Masatoshi" uniqKey="Okamatsu M" first="Masatoshi" last="Okamatsu">Masatoshi Okamatsu</name></noRegion><name sortKey="Isoda, Norikazu" sort="Isoda, Norikazu" uniqKey="Isoda N" first="Norikazu" last="Isoda">Norikazu Isoda</name><name sortKey="Kida, Hiroshi" sort="Kida, Hiroshi" uniqKey="Kida H" first="Hiroshi" last="Kida">Hiroshi Kida</name><name sortKey="Kida, Hiroshi" sort="Kida, Hiroshi" uniqKey="Kida H" first="Hiroshi" last="Kida">Hiroshi Kida</name><name sortKey="Kida, Hiroshi" sort="Kida, Hiroshi" uniqKey="Kida H" first="Hiroshi" last="Kida">Hiroshi Kida</name><name sortKey="Kishida, Noriko" sort="Kishida, Noriko" uniqKey="Kishida N" first="Noriko" last="Kishida">Noriko Kishida</name><name sortKey="Sakoda, Yoshihiro" sort="Sakoda, Yoshihiro" uniqKey="Sakoda Y" first="Yoshihiro" last="Sakoda">Yoshihiro Sakoda</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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